Clinical AI Validation Methods

This research note summarizes practical validation approaches for clinical AI: retrospective benchmarking, prospective pilots, bias assessment, and ongoing post-deployment monitoring.

Key approaches

  • Retrospective benchmarking: Evaluate performance on held-out datasets and across subpopulations.
  • Prospective shadow deployments: Run the model in parallel with standard care to measure concordance and operational impact without affecting decisions.
  • Bias & fairness audits: Compare performance across demographic groups and examine calibration.
  • Continuous monitoring: Post-deployment tracking of drift, outcomes, and adverse events.

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